- Title
- A pig model of the preterm neonate: anthropometric and physiological characteristics
- Creator
- Eiby, Yvonne A.; Wright, Layne L.; Kalanjati, Viskasari P.; Miller, Stephanie M.; Bjorkman, Stella T.; Keates, Helen L.; Lumbers, Eugenie R.; Colditz, Paul B.; Lingwood, Barbara E.
- Relation
- NHMRC.569635
- Relation
- PLoS One Vol. 8, Issue 7
- Publisher Link
- http://dx.doi.org/10.1371/journal.pone.0068763
- Publisher
- Public Library of Science
- Resource Type
- journal article
- Date
- 2013
- Description
- Background: Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages. Methods: Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term = 115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols. Results: Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability. Conclusion: The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes.
- Subject
- swine; neonatal care; piglets; body weight
- Identifier
- http://hdl.handle.net/1959.13/1048845
- Identifier
- uon:14960
- Identifier
- ISSN:1932-6203
- Language
- eng
- Full Text
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